Very, very small section, let me do this in a different color, this little section right over here, zoomed in. So for example this might be a section of a much longer molecule, so the much longer strand of DNA, and even there I'm probably And just to be clear,Īnd we talked about this in the introductory video to DNA, DNA is much more than, you So right over here thisĬould be a fragment of DNA, I have, what, I have- This is eight base pairs depicted. Really just give you theĬonceptual idea of what happens. On a conceptual level, I'm not gonna go into all of the, I guess you could say biochemical details. And what we wanna do in this video is get a better appreciationįor why it is suitable, and the mechanism by which it is the molecular basis for heredity. Talked about how DNA's structure as this double helix, this twisted ladder, makes it suitable for being the Eventually, the RNA transcript is released, and the polymerase detaches from the DNA. In the wake of transcription, the DNA strands re-form a double helix. The polymerase moves downstream, unwinding the DNA and elongating the RNA transcripts 5' -> 3'. After RNA polymerase binds to the promoter, the DNA strands unwind, and the polymerase initiates RNA synthesis at the start point on the template strand. The DNA double helix then unwinds, and RNA synthesis begins at the start point on the template strand of DNA.ġ) Initiation. 3) Additional transcription factors bind to the DNA along w/ RNA polymerase II, forming the transcription initiation complex. 2) Several transcription factors, one recognizing the TATA box, must bind to the DNA before RNA polymerase II can do so. 1) A eukaryotic promoter commonly includes a TATA box, a nucleotide sequence containing a series of TATA, about 25 nucleotides upstream from the transcriptional start point.
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